Beilstein J. Org. Chem.2024,20, 445–451, doi:10.3762/bjoc.20.39
synthetase A (GrsA) in the gramicidin S-producer Aneurinibacillus migulanus ATCC 9999, providing an alternative scaffold to develop novel A-domain inhibitors.
Keywords: adenylationdomaininhibitor; gramicidin S synthetase; natural product; nonribosomal peptide; nonribosomal peptide synthetase
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Graphical Abstract
Figure 1:
Biosynthesis of gramicidin S. Modules comprise the PCP, A, E, C, and TE domains. PCP, peptidyl carr...